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Particularly, the significant variation in inducing conditions such as IL-1, oxidative stress, and iron load across different studies makes it unclear whether SLC7A11 downregulation is a universal mechanism in OA, lacking systematic assessment of consistency across models

The status epilepticus induces neuronal LONP1 upregulation, which maintains neuronal survival during prolonged seizures by clearing excessive mitochondrial active caspase-3 and high-mobility group box 1 (HMGB1) [90]

Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma

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